Gastro retentive drug delivery systems are prepared to enhance stay duration in the stomach for a prolonged period. These systems are useful for the drugs meant for localized delivery into the stomach or are highly absorbed and poorly absorbed from the intestine because of alkaline pH. These techniques help increase the solubility of the drug before gastric emptying and cause enhanced bioavailability. Therefore, we aimed to make gastroretentive floating matrix beads and tablets of the antidiabetic drug Tolbutamide because of the different advantages of gastroretentive drug administration. Floating matrix beads and tablets are dosage forms that are easy to make and can release the medicine for a long time in the stomach. However, the physicochemical properties of tolbutamide need to be investigated to determine whether they support forming gastroretentive floating matrix beads and tablets. Being freely soluble in water, it can be considered a good candidate for gastroretentive dosage forms. It doesn’t show any compatibility issues with the polymer used; hence considered good on the safety issue. In conclusion, Tolbutamide, if used as gastroretentive drug delivery system, may work efficiently and will be able to improve the therapeutic, allowing blood glucose levels to be maintained more effectively