The diverse biological activity, medicinal and agricultural importance of 1,3,4-oxadiazole and thiazole derivatives is well known. Earlier, some compounds were synthesised, by one of the Authors, having both 1,3,4-oxadiazole and thiazole moieties in it. In present paper assessment for physiochemical parameters and toxicity profile of synthesized thiazolyloxadiazolethiols and corresponding thiazolyloxadiazolethiomethyl derivatives has been reported. All studies are carried out using In silico tools. For physicochemical properties, like logP, logD, logS , HLB and pKa ,online web server Chemicalize ChemAxon was used. Toxicity profile was evaluated using Protox-II server for acute toxicity, toxicity targets like organ toxicity and toxicological end points. Various aspects for data of these studies have been evaluated and discussed