Present studies serve as a basis for determining authenticity as well as a way to distinguish it from other species of Morus and develop novel hypocholesterolemic drug. In this work, pharmacognostical, phytochemical and hypocholesterolemic study of Morus alba leaves are described. Under pharmacognostical study, macroscopy and microscopy were conducted. Stomatal numbers, stomatal index, palisade ratio, vein-islet numbers and vein termination numbers were studied as leaf constants