The Siddha system of medicine, which began in the Indian subcontinent, is one of the earliest traditions of healthcare that has been codified. Since ancient days the founders of the Siddha system manuscripted so many medicines preparation. Among that, a Herbo-mineral preparation Perungaya Chooranam (PGC) mentioned in classical text, which assumed to prescribe for gastritis, GERD. In this globalized world drug standardization and publication consider as a master key to propagate the genuineness. Standardization of PGC was done based on PLIM guidelines would be flashes the essential to the westernization.