The goal of this research is to investigate Silene vulgaris’phytochemical composition and COX inhibitory efficacy. Normal additives have been created as an answer for supplant or decrease the quantity of manufactured additives frequently remembered for drug and corrective products. This study planned to evaluate the viability of Silene vulgaris extricate as a characteristic additive in skin cream detailing. S. vulgaris concentrate's antibacterial activity was tried to decide the most reduced inhibitory fixation. The consistency of creams stored at 4, 25 and 37 degrees Celsius was tested in vitro. Beat ultrafiltration fluid chromatography-mass spectrometry was utilized to screen 11 confirmed botanicals utilized in the customary Chinese medication Huo-Luo-Xiao-Ling Dan for ligands to cyclooxygenase (COX). A catalyst measure in light of mass spectrometry was then used to decide the centralization of every one of ligands that repressed COX-1 or COX-2 by half (IC50). With IC50 upsides of around 10 M, acetyl-11-keto-boswellic corrosive, acetyl-boswellic corrosive, acetyl-boswellic corrosive, and betulinic corrosive were COX-1 explicit inhibitors. The concentrate was tested for total polyphenols (TPC), catechins, tannins, and O-diphenols.