A study was conducted to determine the antioxidant potential of methanolic extract Clerodendrum infortunatum Linn. (MECI), which is widely used for many purposes in the Indian indigenous medical system. A variety of well-established in vitro antioxidant tests were used to assess the antioxidant potential, including the reductive power assay, nitric oxide scavenging, superoxide anion radical scavenging, hydroxyl radical scavenging, and total amount of polyphenolic compounds. In every test, MECI was shown to have a high concentration of polyphenolics and strong free radical scavenging action. The presence of the greatest concentration of flavonoids and polyphenolics in it may have contributed to its increased activity.