Background and Aim: Medicinal plants, enriched by nature with potent compounds, hold great promise in developing natural drugs with minimal side effects. This study focuses on Leonotis nepetifolia a plant species renowned for its medicinal potential. We aimed to identify and quantify phytochemicals in its leaf extracts and evaluate their in vitro antioxidant activity. Methods: Methanol, hexane, and water were used as solvents for extraction.Qualitative and quantitative tests were carried out to determine the presence and amount of compounds present in the extracts.To determine the antioxidant activity various assays like DPPH,ABTS,FRAP and Ion chelating assays were carried out Results: Qualitative analysis revealed a range of pharmacologically active phytochemicals, including alkaloids, carbohydrates, glycosides, saponins, proteins, amino acids, phenols, fixed oils, and terpenoids. Methanolic and aqueous extract exhibited the highest diversity, with six distinct compounds. Quantitative analysis showed that aqueous extract contained the most phenols (0.52 mg/g) and carbohydrates (11mg/g), while hexane had the highest flavonoid content (329 mg/g), and aqueous extract displayed the most protein (56.8 mg/g). Antioxidant assays demonstrated the superior performance of aqueous extract, with maximum inhibitory percentages of 73.96% (DPPH), 65.71% (FRAP), 85.07% (ion chelating), and 45.73% (ABTS) indicating its remarkable antioxidant potential. Conclusion: These findings underscore Leonotis nepetifolia as a valuable source for phytochemicals with significant antioxidant properties, particularly in the aqueous leaf extract, holding promise for future therapeutic developments.