A member of the Piperaceae family, which also contains pepper and kava, the betel (Piper betle) is a vine. Most Asian immigrants use betel leaf throughout Asia and abroad in the world as betel quid or paan, along with areca nut and/or tobacco. A preliminary phytochemical screening was performed on the leaves. Objective: The anti-inflammatory qualities of Piper betle leaf extract were investigated in this work. The purpose of this study was to evaluate the physical characteristics and anti-inflammatory activity of the betel leaf extract at 1%, 2% and 4% concentration. Methods: Using the Soxhlet apparatus, an alcoholic extract of leaves of Piper betle was obtained, and its phytochemical screening was examined. The carrageenan induced paw edema model was used to test the anti-inflammatory activity of these dosage forms. Result: The anti-inflammatory activity of Piper betle is maximum at 4% concentration. The phytochemical screening of betle leaf shows the presence of the constituent i.e. hydroxychavicol (polyphenolic component), quercetin (flavonoid), β-caryophyllene (volatile component) and others like alkaloids, saponins, coumarin and glycosides. Conclusion: In conclusion, it has been demonstrated that Piper betle extract has anti-inflammatory properties through a number of methods, such as the suppression of pro-inflammatory cytokines and enzymes.