Pulsatile drug delivery systems are gaining importance in delivering the drug at a specific time as per the pathophysiological need of the disease, which results in improved patient therapeutic efficacy. The present study intended to develop pulsatile tablets of piroxicam using the double-compression coating method. In this study, pulsatile compression-coated tablets were prepared by the direct compression method. The inner compression coat is made of either sodium starch glycolate or hydroxypropyl methylcellulose E100 as a swelling layer. The outer compression coat (release controlling layer) was prepared using different polymers like ethyl cellulose, hydroxypropyl cellulose, sodium alginate, and hydroxypropyl methylcellulose K 15M and characterized for various parameters. From the in vitro drug release studies, F14 pulsatile tablets were considered the best formulation, and the percent drug release in 12 h was found to be 98.68±0.76%. The release process followed super case-II transport with zero order release kinetics. FTIR studies proved that there were no drug-excipient interactions. The best formulation showed good stability from the stability studies, and it was established by calculating the similarity factor, i.e., 82.39. In conclusion, developing piroxicam double-compression coated pulsatile tablets is a promising way to control drug release as per the therapeutic requirement.