It has proven to categorise and treat depression as a range of mood disorders. Due to its widespread applicability and medicinal efficacy coupled with minimal adverse responses, ayurvedic drugs are utilised more frequently than synthetic ones around the world. This has led to the initiation of scientific investigations associating the antidepressant activity. The most common forms of medications used for the treatment of depression are antidepressants. Antidepressant medications come in a wide variety, and the only things that set them apart from one another are how they work in the brain, how much they cost, and how many side effects they have. The alkaloids obtained from various plants’ seeds, bark, & roots are only a few of the elements that have been utilised traditionally in medicine. The primary focus of this review is the clinical behaviour of a plant-based alkaloid (the primary intermediate metabolites) as a potential brand-new treatment for depression.