A pot experiment was conducted in natural environmental conditions in the experimental locality of Government College Woman University, Faisalabad, to investigate the effect of TNPs along with drought conditions on wheat (Giza 129 and Giza 133). The physiological and morphological attributes are studied. The soil used for this analysis was artificially spiked at different drought levels (30 % FC and 60% FC) and different levels of Titanium based (TNPs) were supplied to plants (4 and 5mg TNPs) to minimize effect of drought. The results of the present study revealed that the titanium NPs have capabilities to deeply interact at tissue level and play an active role in increasing their physiology under drought stress. It was shown that plant growth and biomass, photosynthetic pigments, gas exchange parameters and stomatal conductance properties were varied significantly (p < 0.05) by drought stress. The root and shoot fresh weight as well as dry weight and root length were increased under higher dosages of TNPs. The physiological attributes like photosynthetic pigments Chl a and Chl b contents were maximum at high doses of TNPs under 60% FC. Stomatal conductance (SC), net photo synthesis were minimum at low doses of TNPs. The concentration of antioxidants enzymes were increased under 60% FC as compared to 5mg TNPs in Giza 129 and increased in Giza 133. Pearson correlation coefficient, representing varietal differentiation and correlation in the physiochemical and morphological attributes. It is concluded that TNPs are effective to counteract the effects of drought stress and also have ability to enhance growth and metabolic activities of wheat.