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ISSN 2063-5346
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Plasma Von Willebrand Factor Level and Hepatic Microvascular Thrombosis in Acute-on-Chronic Liver Failure Patients

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Ramy Adel El-Shahat Musa ; Yasser Ahmed Fouad El Naggar ; Ehab Fawzy Abdelaziz ; Sally Mahmoud Saeed Shalaby ; Samar Mohamad Shehata, Rabab Mahmoud Elfwakhry Mahmoud mohamed Amer
» doi: 10.48047/ecb/2023.12.sa1.526

Abstract

Background: Acute-on-chronic liver failure (ACLF) is associated with features of systemic inflammation. Plasma VWF levels are increased 5:7 fold in patients with ACLF. The imbalance between VWF and ADAMTS13 in sepsis/inflammatory conditions can be a predisposition to platelet microthrombi and an impedance to vital organ microcirculation.

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