Cissus quadrangularis is a widely known herb in India and south India in particular.It is widely mentioned in ancient Indian medical texts.The bone healing ability of CQ is outlined in Ayurvedhicmedicine.However ,research on effect of CQ in humans are few and far.This review tries to give a clear picture on the available literature that describes the osteogenetic role of CQ in general and mandibular bone in particular.CQ is suggested as a plant herb in treatment of bone fractures and bone loss as it is safe or usage and side effects are not identified so far.