Polycystic Ovarian Syndrome (PCOS) has become a common physiological disorder affecting the menstrual cycle and fertility in women. The hormonal imbalance can cause acne, facial hair growth, balding and overweight and may also lead to life threatening conditions including hypertension, kidney problems, type II diabetes, cardiovascular disease and heart disease if left untreated. Homoeopathy has a significant role as an alternative treatment in the cases like polycystic ovarian disease where conventional treatment fails to improve or cure the patient. The present case report presents a 28 year old female with complaints of secondary amenorrhea since past 3 months, scanty menstruation since past one year and severe pelvic pain. She visited the outpatient department of SKS Homoeopathic clinic Chrompet, Chennai in the month of November 2021. History revealed that she was suffering from PCOS since menarche and she was under allopathic treatment for a period of one year with no progressive improvements. Her ultra sonogram (USG)-pelvis revealed the confirmatory diagnosis of Polycystic ovaries. The patient was treated with homeopathic medicine Sepia a day for a period of 90 days after which she was showing signs of improvement in her symptoms of menstrual flow and pelvic pain. The follow up USG abdomen revealed the successful outcome with absence of cyst and reduction in ovarian size and volume. The present case report support the use of Homeopathic natural source medicine towards the management of Polycystic Ovarian Syndrome (PCOS)