The medicinal product of A.eupatoria reduces liver damage by preventing TLR-4 signaling in the liver. Hepatitis surface antigen release was suppressed by aqueous extracts made from the aerial portions of A.eupatoria. Due to its lipid-lowering and antioxidant properties, the extract has been demonstrated to protect against liver damage. Plants of the genus Agrimonia, including A.eupatoria, have potential antiviral action against the hepatitis B virus in their aqueous extract made from their aerial portions. These findings suggest that A.eupatoria dry herb extract has a strong hepatoprotective effect, lowers the amount of lipid peroxidation, and stabilizes the outer membrane structure of liver cells.