COVID-19, apart from becoming the greatest threat to global public health of the century, is being considered as an indicator of inequity and deficiency of social advancement. As is implied in the name COVID-19, ‘CO’ stands for ‘corona,’ ‘VI’ for ‘virus,’ and ‘D' for disease, and 19 represents the year of its occurrence. During the pandemic, various COVID-19 treatment strategies have been developed and widely introduced to clinical practice. Antimalarials and some antivirals, such as lopinavir and ritonavir, which had been used at the early stages of the pandemic, were later found to be ineffective and/or associated with risks to patient health. To date, an effective curative therapy that can be used in a wider population is still lacking. Therefore, only symptomatic and pathogenesis-based treatments are available, even for patients with moderate to severe disease. In such a situation, the most promising strategy for overcoming the pandemic is vaccination of the entire population. Vaccines represent one of the most critical advances in medicine and are the most effective method to prevent morbidity and mortality associated with infections. However, unlike antimicrobial agents used to treat infected persons, vaccines are applied to healthy subjects to prevent infections; therefore, adverse effects acquire great relevance. Nevertheless, adverse effects do not outweigh the indisputable advantages vaccines offer to humanity by preventing diseases that constitute a significant economic, social, and familial burden. In this manner, informing individuals, families, and communities of the characteristics of vaccines makes the risk–benefit of each of the vaccines more familiar, doubtlessly contributing to the population’s health