A 25-year-old female post-partum day 15 presented with high grade fever, generalized weakness, vomiting, disoriented to time place and person. On examination, patient was anaemic, febrile and stuporous. Investigations revealed hypernatremia, hyperuricemia, acute kidney injury and features suggestive of extra-pontine myelinolysis on magnetic resonance imaging (MRI) of brain. After correcting hypernatremia, there was a gradual improvement in neurological symptoms of the patient. Extrapontine myelinolysis, a fairly common metabolic disorder, is associated with neurological complications. Central pontine and extrapontine myelinolysis are commonly recognized with rapid correction of sodium. Myelinolysis, however, has rarely been described with hypernatremia. Neuroimaging findings can be crucial in diagnosing hypernatremic encephalopathy in the postpartum period.