Data from the IDF (International Diabetes Federation) shows that Indonesia is in fifth position in the world and this number continues to increase every year, so glycemic control is needed in the form of drugs for this complication of diabetes mellitus. Treatment with herbal plants is safer than synthetic chemical drugs. One that is widely used is senggani plant. The researcher conducted an experimental research using The Post Test Only Control Group Design, 35 samples was randomly selected and divided into 7 groups. All groups were induced with Streptozotocin (STZ) 45 mg/kg BW to make the rats DMT2 and given High Fat Diet food and sucrose drinks. Group K- was not given any treatment, K+1 was given Metformin, K+2 was Metformin+Gengigel, P1 was only given Senggani leaf ethanol extract (EEDS) 500 mg, P2 (EEDS 500 mg + 5% EEDS gel), P2 (EEDS 500 mg + 10% EEDS gel) and P2 (500 mg EEDS + 15% EEDS gel). After 3 days of being induced by STZ, given treatment (Day 1) by first anesthetizing with ketamine 100mg/10ml, 20-40 mg/KG BW, a surgical wound was performed using a tissue punch with a diameter of 2.5 mm and a depth of 3 mm, Blood Glucose Levels, TGF β1 was measured. The normality and homogeneity results (Sig. TGF β1=0.219) were not significant on day 1 to day 16 because p>0.05 , while the One Way Anova test was significant p<0.05 , this indicated that there was an effect of treatment. The Post Hoc test in the form of the Tukey test showed that the P3 group was the most effective because EEDS contained tannins, saponins, flvonoids, phenols and glycosides, followed by K+2, while K- did not show much healing because there was no treatment for this group.