Herbal drug delivery is limited by poor solubility and bioavailability which can be overcome with suitable nanomaterials that will enhance their pharmacokinetics and performance. In this study, we hypothesized that loading extract of Gynocardia odorata into nanoparticles to improve its oral bioavailability and hence the effectiveness of the extract in Antioxidant and Hepatoprotective Activity. Gynocardia odorata extract loaded solid lipid nanoparticles (GSLNs) were prepared using Solid lipid (Acconon C-44 EP/NF) and coded as F1 to F8. The GSLNs were evaluated for their size, surface charge, and morphology, entrapment efficiency, stability studies. The optimized GSLNs were tested for anti-diabetic activity in male Swiss albino rats. The SEM study revealed that the optimized GSLNs (F5) formulation was fairly spherical in shape, the surfaces of the particle showed a characteristic smoothness. From the data, it was found that the F5 formulation shows least particle size of 169.5± 7.24nm, maximum percentage entrapment efficiency of 85.38± 1.24% and desired zetapotential of about -36.1± 1.2mV. From the stability study data, it shows that there was no drastic change in evaluation data of F5 formulation during manufacturing and after storage at stress condition at 4˚± 2˚ C. In the current work, loading Gynocardia odorata extract into SLNs proved to be an effective strategy in improving the pharmacological activity. Moreover, at lower doses, the GSLNs demonstrated similar, if not superior antioxidant and hepatoprotective Activity compared to the crude extract. This opens up avenues to explore SLNs as carriers for effective delivery of phytopharmaceuticals.