Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Cocrystallization is a technique to optimize solid forms that shows great potential to improve the solubility of active pharmaceutical ingredients (APIs). Dapsone belongs to a class of drugs called Ant leprosy Agents. Dapsone is classified as a class II drug according to the Biopharmaceutics Classification System, which exhibits high permeability and low solubility and hence results in low bioavailability. The present work illustrates the attempt to improve the solubility of dapsone via a crystal engineering approach. Solid form of dapsone with saccharine cocrystals was obtained through solvent evaporation method. Cocrystals are characterized by differential scanning calorimetry, Fourier transform infrared spectroscopy. It was predicted that two molecules are associated through a hydrogen bond. The cocrystals exhibited faster dissolution rate owing to co crystallization as evident from 2.8 times increase in the extent of dissolution.