Gastro retentive drug delivery systems stay in the stomach for a long. These are a vital option for the drugs that get dissociated into the GI tract and doesn’t get solubilized in the intestinal environment owing to their alkaline pH and hence necessitate their retention in the gastric (acidic) for improvised bioavailability. Such technologies are more effective in strengthening the gastrointestinal absorption of drugs with narrow absorption windows and controlling the release of pharmaceuticals with site-specific absorption restrictions. Because of the several advantages of gastro retentive medication administration, we set out to create a gastroretentive floating matrix tablet of the antidiabetic drug Tolbutamide. Floating matrix tablets are a simple unit dosage form that benefits from releasing medication for an extended period in the stomach. Anti-diabetic drugs would have a better therapeutic impact with this dose form, allowing blood glucose levels to be managed more efficiently. The preparation and evaluation of the gastroretentive floatable matrix tablet of the antidiabetic drug Tolbutamide are explained in this study.