Depression is a psychological disorder affecting different age groups belonging to different countries and cultures. It was estimated that around 264 million individuals of all ages suffer from depression globally. Thus, much research is carried on establishing significant advancement in diagnosis and treatment of the depression. The purpose of this study is to prepare and evaluate nasal gel formulation containing paroxetine hydrochloride and establishing the effect of different excipient on drug release and nasal absorption, evaluation of physiochemical properties of nasal gel and evaluating their stability during storage condition thereof