A Polyherbal formulation, syrup is in clinical use for its anthelmintic activity for last few decades. However, no systematic study on its therapeutic/pharmacological effect is reported. The current research work was under taken to evaluate the anthelmintic property of some herbs and compare with the marketed formulation. The present study was to attribute the pharmacological effects to individual constituent as the formulation is of polyherbal nature. Prepared Curcuma longa and Moringa oleifera syrup show synergistic effect that’s why formulated syrup is more effective than marketed albendazole syrup. Stability studies also concluded that the drug release profile or other parameters did not alter significantly after the accelerated stability studies. The study indicates that Polyherbal syrup i.e. Curcuma longa and Moringa oleifera will offer an option which is more convenient, effective and cost effective as compared to the marketed formulation.