Background: In this article, we constructed a very novel carrier in the form of nanoparticle which is core shell structure and applied for the delivery of the curcumin to examine the toxicity and dose profile of the drug. Side by side its controlled release behavior of curcumin due to use of this carrier i.e. Silica nanoparticle. The nanocomposite structure was prepared by the simple process the mesoporous silica nanoparticle seen to be higher surface area. It also provided a large accessible volume for the good absorption of the drug.