AIM/ OBJECTIVE: The objective of the study is to prepare the dual gel using nutmeg and tulsi and then the evaluation of antimicrobial property and the cytotoxic potential. MATERIALS AND METHODS : The gel preparation has been done by mixing the powder of nutmeg and tulsi.Then to this mixture 5ml of the concentrate is added and mixed thoroughly until the proper gel formation is done. The antimicrobial property is checked in the Porphyromonas gingivalis organism. The cytotoxic potential is checked in the Braine variety of the shrimp. Results : the results stated that the nutmeg and tulsi gel is having high antimicrobial potential in case of Porphyromonas gingivalis. CONCLUSION : The antimicrobial property of Nutmeg tulsi gel has been demonstrated to be effective against P.gingivalis. This suggests that it could be used as an affordable and effective "adjunct" alongside standard care for managing periodontal conditions.