This research work mainly focuses on preparation and characterization of lignin nanoparticles from coconut waste of Cocos nucifera L and determination of its antiviral potential. Lignin nanoparticles were prepared successfully by alkaline extraction method. Further the nanoparticles were tested for antiviral potential against SARS- Covid 19 virus using silver nanoparticles as a control with the help of BioRad CFX 96qRT-PCR machine. Covid-19- delta variant when added with lignin nanoparticles values changed with a large difference, for FAM value changed from 24.21 to 34.66, for Texas red from 26.38 to 32.33 and for VIC from 25.62 to 33.08. This large increase in cq values suggesting that RNA genome is degraded after reacting with lignin nanoparticles. This type of degradation is also observed when covid-19-delta variant was added with silver nanoparticles but the maximum degradation was observed when lignin nanoparticles were used.