Introduction: Coat buttons, or Tridax Procumbens, are members of the Asteraceae family. It is a perennial herb with a spreading stem that can grow to be between 8 and 30 inches long. The most common usage of this plant is as a weed and pest that has a variety of functions, including antifungal, anticoagulant, and wound healing. Local healers in India also apply them to the treatment of cuts, blisters, and boils. Materials and Methods: To prepare the extract, 5g of T. procumbens leaves and stem powder were dissolved in 50 mL of distilled water, heated for 5 minutes, and then filtered through whatman filter paper. The agar well diffusion method was used to test the extract's antimicrobial effectiveness at different concentrations (25 μL, 50 μL, 100 μL) against more common oral pathogens. Results: The results of the current study showed that the antimicrobial activity of T. procumbens leaves and stem extract was highest at concentration of 100 μL. The leaves extract showed maximum antimicrobial activity against S. aureus whereas the stem extract showed maximum antimicrobial activity against S. mutans. Conclusion: The present study demonstrated an eco-friendly and cost-effective synthesis of plant extracts from stem and leaf of T. procumbens. These plant extracts showed potent antimicrobial activity against common oral pathogens assuring its effective therapeutic application in several oral infectious diseases.