Haemorrhoids or piles are the pathological condition, characterized by vasodilation and inflammation in the ano-rectal region, which causes increased permeability of blood vessels and induce oxidative stress in the ano-rectal tissues. Prevalence of Haemorrhoid has been estimated as 50-85% of the total population globally and 75% in India. Although the initial stages of haemorrhoid is manageable with medication i.e., for grades one to three; the disease needs surgical intervention for grade four where in prolapse is irreducible. From time immemorial, through traditional and ethnomedical practice, the disease haemorrhoid has been effectively managed with plant based remedies as well as dietary modifications. Mayurasikha is one such drug, having anti-inflammatory and anti-oxidant properties, used by the tribes to treat haemorrhoids and is botanically identified as Actiniopteris radiata (Sw.) Link belongs to the family Pteridaceae. To scientifically evaluate the anti-haemorrhoidal potential of paste of Actiniopteris radiata (Sw.) Link (Mayurasikha) with milk internally, an in- vivo study has been designed in Wistar Albino Rats. The study was carried out in six groups namely, Normal control group, Positive control group, Standard drug group, Trial drug paste mixed with un-boiled milk group, Trial drug paste mixed with boiled milk group and Trial drug paste group and containing six rats in each group. For the purpose of inducing haemorrhoids, croton oil preparation was used in all the groups except Normal control group. Standard drug group and trial drug sample groups were given respective treatments for a period of seven days. On the seventh day the animals of each group were sacrificed under deep ether anesthesia and Ano-rectal tissue were collected for histopathological evaluation. The results were statistically analyzed using Wilcoxon signed rank test. Among the groups, only trial drug paste with boiled milk group exhibited statistically significant changes justifying the traditional claim of Mayurasikha paste mixed with boiled milk group in the treatment of Haemorrhoids.