Recent biomarkers and inflammatory variables could contribute to early prompt identification & differentiation of septic patients from those with SIRS. Among different recent biomarkers that appear to be promising in diagnosis of early stages of septic process were procalcitonin, presepsin, IL-6 and CD64. Now there is multiple studies act on the important role of presepsis in patients with liver cirrhosis and bacterial infection. Bacterial infections complicate the course of liver cirrhosis and determine an increased rate of decompensation, acute-on-chronic liver failure, and mortality. The early diagnosis and prompt treatment of infections prevent liver cirrhosis from further decompensation and sepsis development and may decrease mortality rates. The serum presepsin level >980 pg/ml had the most appropriate specificity and sensitivity to identify bacterial infections in patients admitted with liver cirrhosis and overt hepatic encephalopathy. Moreover, the presepsin levels were directly correlated with liver cirrhosis severity assessed by the MELD score and the Child-Pugh class. This review article aiming to discuss Presepsin and Other Inflammatory Markers among Cirrhotic Patients with Bacterial Infections. Data were collected from review articles extracted from pub med and google scholar from 1990 till 2022.