Background: Migraine is a chronic unilateral headache associated with nausea and vomiting. According to the World Health Organization, it is listed as the 19th disabling disease. Multiple studies found an inverse relationship between the frequency of the attacks and the low quality of life score. Roughly, one-third of migraine attacks occur during workdays, with a higher incidence of reduced productivity and missed days among chronic patients (>15 headache days per month). Migraine is a common neurological disorder with significant impact on quality of life, affecting 12% Saudi population. migraines impose significant health and financial burdens, headache is a common neurological disorder, which is associated with a significant disease burden, headache affects work, social and leisure activities and has a tremendous impact on a person’s life also the migraine is one of the most critical concerns among healthcare providers and other relevant stakeholders in the health sector. Aim of the study: To assess the prevalence and impact of Migraine headache among physicians in PHC centers in Makkah City, Saudi Arabia, 2021. Method: Across-sectional study among physicians who works in primary health care center in Makkah Al-Mukarramah 2021, the study has been conducted physicians who works in PHC centers in Makkah city KSA. Was conducted using an online questionnaire designed during August 2021. The questionnaire collected the socio-demographic factors, a migraine screen questionnaire (MS-Q) Migraine. Disability Assessment questionnaire (MIDAS), our total participants were (200). Result: Shows that most of the participants (59%) were in the age group(25-50) years follow by the (21.0%)were in the age (<25) years, the majority of them females was higher compared to male(66.0 and 34.0%) , regarding the Nationality most of participants non-Saudi were were(63.0%), regarding the marital status most of participants married were(56.0%), regarding level of education the majority of participant are specialist were(54.0%) while general practitioner were(23.0%) Conclusion: For migraines, our study found a high prevalence of the migraine in among physicians who works in primary health care center. The physicians’ awareness of the disease was very low with one-fourth of the physicians resorting to self-medication.