Helicobacter pylori (H. pylori) infection affects approximately one half of the world population and it is more prevalent in developing countries. The prevalence of H. pylori infection in pregnant women varies according to geographic area, socioeconomic conditions and method used to detect H. pylori infection. Aim: to assess Prevalence of Helicobacter Pylori Infection in pregnant women with iron deficiency anemia and intra uterin growth retardation. Methods: This cross sectional study was carried out from February 2021 to August 2022 at obstetrics & gynecology and microbiology departments, faculty of medicine, Zagazig University, This included 256 pregnant women attending antenatal clinic during the period of the study, The presence of H. pylori antigen in the faeces provides unmistakable proof of bacterial colonization in the GIT. Results: among the studied cases there were 68 (28.5%) who had helicobacter pylori, there was statistically significant relation between helicobacter pylori and iron deficiency anemia, as well as Intrauterine growth restriction (IUGR). Conclusion: H. pylori infection was investigated not only in association with gastrointestinal manifestations during pregnancy but also with other severe pregnancy-related disorders. There was statistically significant relation between helicobacter pylori and iron deficiency anemia & IUGR.