Background In its plan for the prevention, treatment and overcoming of mental health disorders, the World Health Organization described mental health as fundamental to human health. Yet, mental health problems are the first cause of disability and a major public health issue worldwide due to disease progression, difficulties in therapeutic management and increasing prevention. Specifically, depression, anxiety and stress are considered important indicators for mental health which, if untreated, can have a negative effect on individuals. Overweight and obesity among health care worker is a major concern for the health care worker. Although health care worker are required to meet body weight and body composition standards, the prevalence of overweight and obesity has risen such that in 2017, over 17% were considered obese based on a body mass index (BMI) of ≥30 kg/m2.1 health care worker with a higher BMI have an increased risk of injury and illness. Aim of the study: To assessment of the prevalence of stress and its association with Body Weight Among health care worker in Primary Health Care Centers in makkah 2020 Method: Cross-sectional analytical study has been conducted health care workers at Primary Health Care Centers in Makkah city, that included all health care worker during data collection period 2022 the perceived stress scale-10 questionnaire used to measure the stress score. Weight and height were collected based on self-reported value. The total sample has been (400) nurses, physicians and other Result: the majority of the respondents were married status were (75.0%) while other were (14.0%). The association between the stress and stress score most of the participant moderate Stress were constitutes (47.75%) followed by low stress the were constitutes (44.75%) while a statistically significant (P-value =0.001)and Chi-square (120.665) ,the Range(5-45) (Mean ± SD (25.441±6.125). Conclusion: Stress is prevalent among health care worker at Primary Health Care Centers, makkah we found a positive correlation between BMI and stress but no statistically significant association between gender and stress level. Preventive measures should be implanted to reduce the level of stress and interventional studies are needed among health care worker at Primary Health Care Centers.