The incidence of PONV could be as high as 70% to 80% in high-risk populations, including feminine sex, obese patients, patients under the age of 40, nonsmokers, patients with a history of PONV, or patients who experience motion sickness, even if the condition is typically self-limiting or treated without side effects. Objectives: The purpose of the study was to find out which % of dextrose infusion reduced postoperative nausea and vomiting in female patients having laparoscopic cholecystectomy. Materials and Methods: This prospective, double-blind randomized placebo-controlled study comprised of 180 ASA physical status I and II patients, 18 to 65 years of age, scheduled for laparoscopic cholecystectomy. Patients were arbitrarily divided into three study groups of 60 patients each. Group A received 2% dextrose, group B received 5% dextrose and group C received 10% dextrose. The primary objective of this study was to compare the incidence of PONV in the study treatment groups. The secondary outcomes included measurement of antiemetic medication consumption between groups. Results: One hundred and eighty patients were enrolled and completed the study. Baseline demographic data of participants including age, ASA class, BMI and duration of surgery were comparable between the two groups and were also statistically non-significant. There was statistically significant difference in PONV score, time to PONV, requirement of rescue antiemetic and PACU stay in study groups (p<0.05) Patient satisfaction was also significantly different between three groups when chi-square test was applied (p<0.05) Conclusion: We believe that using IV dextrose 2%, as low-price antiemetic prophylaxis in patients undergoing any laparoscopic surgeries, provides opportunities for substantial cost saving while preserving efficacy