Fibrosis is characterized by excessive accumulation of extracellular matrix components within organs and tissues. Genes play a vital role in determining the course of fibrosis. Numerous genes are either up-regulated or down regulated during the fibrotic disease process. Pro-fibrotic genes propel the disease towards fibrosis while antifibrotic genes down regulate the process of fibrosis. Knowledge regarding these genes could help in development of targeted strategies to alleviate fibrosis in various organs. The current article is prepared mainly using data collected from PubMed, cochrane and MEDLINE databases.