To evaluate the impact of diabetes mellitus on dental implant failure rates and marginal bone loss (MBL). Material and methods: The researchers conducted an electronic search in three databases and manually searched journals to gather information. They performed meta-analyses and meta-regressions to determine the relationship between odds ratio (OR) and MBL with follow-up time. The review consisted of 89 publications and included data on 5,510 implants placed in diabetic patients and 62,780 implants placed in non-diabetic patients. Results : The researchers found that in pairwise meta-analysis, the risk of implant failure was higher in diabetic patients compared to non-diabetic patients (OR 1.777, p < 0.001). Type 1 diabetes patients had a higher risk of implant failure compared to type 2 diabetes patients (OR 4.477, p = 0.032). This difference was statistically significant in the maxilla but not in the mandible. The mean difference (MD) in MBL between the groups was 0.776 mm (p = 0.027), and the MBL MD increased by 0.032 mm for every additional month of follow-up (p < 0.001). Additionally, the OR decreased by 0.007 for every additional month of follow-up (p = 0.048). Conclusion : Implants in diabetic patients showed a 77.7% higher risk of failure than in non-diabetic patients