A deeper understanding of cancer cells and molecular risk stratification is provided by research into the genetics of MM. There are molecular anomalies that put 20% of patients with newly diagnosed multiple myeloma (NDMM) at high risk. All MM patients are said to have cytogenetic abnormalities, sometimes even as the illness progresses. Aim: To assess the prevalence and prognostic importance of del(13q14) detected by interphase Fluorescence In Situ Hybridization (FISH) in Egyptian patients with newly discovered multiple myeloma. Patients and methods: The study comprised 66 patients of Multiple Myeloma (MM) with a recent diagnosis. They all gave presentations at the medical oncology clinics at Cairo University's National Cancer Institute (NCI). All cases were subjected to special laboratory investigations (FISH) for detection of del(13q) using 13q Locus specific probes (Vysis). Results: Del(13q14) was detected in 13 patients (19.7%) and was associated with significantly worse disease-free survival, but did not impact overall survival. Conclusion: FISH technique is preferable for detection of cytogenetic abnormalities.