Chewing gums are mobile drug delivery systems, with a potential for administering drugs either for local or systemic absorption via buccal route. It can be administered discreetly without water. Medicated Chewing Gums contains gum base along with antiemetic agent which is intended to chew not to be swallowed. These formulations contain Promethazine, Polyvinyl alcohol, Carboxymethyl agorase, Peppermint oil, Polyethylene glycol (PEG-400), Calcium carbonate, Synthetic gum base, Propyl paraben, and Ascorbic acid. The medicated chewing gums were prepared by the direct compression method. The prepared formulations were evaluated for various pre-compression and post-compression parameters. The in-vitro drug release of Formulation F7 showed satisfactory drug release within 30 min at various chewing conditions. From the results, it is concluded that the chewing gum containing Promethazine HCl will be the potential dosage form for the treatment of chemotherapy induced nausea and vomiting.