Ensuring a culture of safety within healthcare organizations is paramount to improving patient outcomes and reducing medical errors. This review article explores various strategies and initiatives aimed at fostering a culture of safety in healthcare settings. By examining the importance of leadership commitment, staff engagement, continuous training, and effective communication, this paper highlights the key components necessary for creating a safe and reliable healthcare environment. Additionally, the role of technology, data analysis, and quality improvement programs in enhancing safety practices is discussed. Through a comprehensive analysis of current literature and case studies, this review provides valuable insights into the challenges and opportunities associated with promoting a culture of safety in healthcare organizations.