Physicians play a vital role in combating pharmaceutical non-adherence, but they are not alone in this effort. Chemists and nurses, who possess diverse areas of expertise, also play a crucial role in this sector. By working together with doctors, they can provide comprehensive care and support to patients. It is important to establish clear guidelines for interprofessional collaborations to avoid duplication of care. Nurses and chemists are uniquely positioned to monitor and encourage medication adherence, communicate with doctors, and ensure continuity of treatment beyond the doctor's visit. Nurses excel in helping patients make lifestyle changes, while chemists are skilled in using medication to reinforce positive behaviors. Both professions are capable of assessing and promoting drug adherence, but they approach it in different ways to meet the specific needs of chronic patients in evolving care models. Medication non-adherence is a significant issue in healthcare, particularly in primary care settings. Research shows that overall patient adherence does not significantly improve with any single approach or program focus. However, interventions that integrate cognitive, behavioral, and emotional components tend to be more effective than individual strategies. By promoting best practices, behaviors, and technological advancements, medication adherence can be greatly enhanced.