The study reflects on the effects of HIV infection on the mental health of patients and the reduction of confidence among HIV patients due to poor mental health. Investigating the crucial role of nurses for protecting the confidence and improving mental health of HIV patients is the core purpose of this study. Materials and methods: Secondary sources such as articles, journals and others have been used for collecting relevant data as well as narrative analysis processes have been adopted for evaluating all the findings. Results: As a result, it is identified that only nurses spend most of the time with HIV patients and they can maintain a positive relationship with them to motivate them. Human interaction is important for the patients to protect their confidence and that can be possible by only nurses as others are generally not allowed. Therefore, it can be stated that nurses have a great role in protecting the confidence of HIV patients which is essential for their faster recovery. Keywords: HIV patients, nurses, mental health, confidence, infectious, interaction, positive relationship