Monosodium glutamate (MSG) is used as a flavor enhancer with the aim of increasing sweetness and saltiness, and reducing sourness and bitterness. L-glutamate binds to taste cell receptors in the taste organ and gives rise to the umami taste, which is the characteristic flavor imparted by MSG. There is an effect of Monosodium Glutamate (MSG) on organ damage, increased cardiovascular risk factors and resulting oxidative stress due to ROS. To prevent the undesirable effects of free radicals, antioxidants are needed. One of the plants that can be used as a natural medicine and rich in antioxidants is the Java Wood plant (Lannea coromandelica). It is known that the stems and leaves contain saponins, flavonoids, and tannins. Flavonoids can function as antioxidants that prevent free radicals. This study aims to determine the protective effect of Lannea Coromandelica extract on the levels of LDH enzymes, CK-MB, and MSG-induced heart histology. Rats were divided into five treatment groups (KS = 0mg, KN = 3 ml/gBB, KPA = 250mg/KgBB, KPB = 500mg/KgBB, and KPC 750mg/KgBB), each group consisting of 6 rats. MSG administration was carried out for 28 days, then examined LDH enzymes, CKMB and heart histology. The results of LDH enzyme levels, CKMB were analyzed using one-way ANOVA test while the percentage of histological damage was analyzed using Kruskal-Wallis test. The results showed that there was a significant difference in blood CKMB levels (p<0.05), while blood LDH levels did not show a significant difference (p>0.05). It was concluded that dosing MSG and Lannea Coromandelica Extract for 28 days can cause mild damage to the histological structure of the rat heart and no visible effect on LDH levels.