Monosodium glutamate is associated with kidney toxicity because it has normal glutamate levels. Lannea coromandelica extract contains secondary metabolites such as alcohols, steroids, triterpenoids, phenolics, flavonoids, tannins, and saponins. This compound is a group of bioactive compounds that produce antioxidant, anti-inflammatory, antibacterial, anticancer and immunomodulatory activities.There are effects of Monosodium Glutamate (MSG) on organ damage, increase in cardiovascular risk factors and result in oxidative stress due to ROS. To prevent the unwanted effects of free radicals, antioxidants are needed. One of the plants that can be used as a natural medicine and is rich in antioxidants is the Java Wood plant (Lannea coromandelica). This study aims to determine the protective effect of Lannea Coromandelica extract on MDA, urea, and serum creatinine levels and renal histology induced by MSG. Rats were divided into five treatment groups (KS = 0 mg, KN = 3 ml/gBB, KPA = 250 mg/KgBB, KPB = 500 mg/KgBB, and KPC 750 mg/KgBB), each group consisted of 6 rats. Administration of MSG was carried out for 28 days, then examination of serum MDA, urea and creatinine levels and renal histology. Results of MDA levels, urea, serum creatinine were analyzed using one way ANOVA test while the percentage of histological damage was analyzed using the Kruskal-Wallis test. The results showed that there were significant differences in blood levels of urea and creatinine (p<0.05), while blood MDA levels did not show significant differences (p>0.05).