Monosodium glutamate (MSG) is the sodium salt of glutamic acid which has been consumed widely throughout the world as a food flavor enhancer. Monosodium glutamate (MSG) is classified as a safe substance, but long-term consumption of MSG causes a number of toxic effects and is considered an excitotoxin, causing harmful effects on organs such as liver toxicity. MSG accumulation can cause hepatocyte damage due to the effects of free radicals, so important substances such as antioxidants are needed to reduce the negative effects of free radicals. The content of Java wood ( Lannea coromandelica) was obtained, namely flavonoid compounds, terpenoids/steroids and tannins which are antioxidants so that they can overcome and prevent free radicals. The purpose of this study was to determine the protective effect of Lannea coromandelica extract on MDA, SGOT/SGPT levels and histopathology of rat liver induced by MSG. There were 5 treatment groups including healthy control (KS) without treatment, negative control (KN = MSG 3mg/BB, treatment control (KPA= extract 250 mg/kgBB + MSG), (KPB = extract 500 mg/kgBB + MSG) and ( KPC = extract 750 mg/kgBB + MSG) orally. After 28 days blood and liver samples were taken. Data were analyzed using the ANOVA test on MDA, SGOT/SGPT levels in blood and Kruskal-Wallis test on liver damage level analysis The results showed that there were significant differences in blood levels of MDA, SGOT and SGPT (p<0.05), whereas there were no significant differences in the histopathological structure of the liver (p>0.05).The conclusion of this study was that MSG administration and Lannea coromandelica extract for 28 days can cause mild damage to liver histopathology and affect liver MDA, SGOT and SGPT blood levels.