Diabetic nephropathy is an end stage renal disease that has potent involvement of oxidative stress, pro-inflammatory cytokines and many other pathways in its pathogenesis. We hypothesized the eriodictyol, a bioflavanone could protect from ensuing renal impairment in diabetes by altering the oxidative stress and inflammatory pathways in renal cells. The aim of study is to investigate the nephroprotective effect of in STZ induced diabetic experimental rats. Eriodictyol treatment for four weeks in two doses (1mg/kg and 10mg /kg) post induction of diabetic nephropathy, highly significantly ameliorates the renal functions impairment, inflammatory cascades and impaired oxidative stress. Eriodictyol also restores the kidney weight, kidney index, feed/water intake and body weight. Eriodictyol significantly attenuates the lipid profile by restoring the LDL, VLDL,HDL,TC and TGs level in serum. Eriodictyol 10 mg /kg treatment also provides a remarkable effect on Advanced Glycation End Products generation in renal tissue. Moreover, Eriodictyol also provides diminution of the pro inflammatory cytokines like IL-6,TNF-α,TGF-β1 synthesisin kidney homogenate. These results illustrate thateriodictyol exhibits the kidney protective effect in experimental rats by playing the antihyperglycemic role by increasing the insulin level in blood which was accompanied by diminution of oxidative and inflammatory cascades