Background: To study psychological affection in rheumatoid arthritis patients in relation to disease activity. Materials & methods:A total of 60 subjects were enrolled. They were divided into two groups as group 1- rheumatoid arthritis and group 2- control group. Each group has 30 subjects. Chi-square test were used throughout to analyze correlation between disease activity scores and psychological signs, as well as significance of differences between RA patient group and their healthy counterparts; statistical significance was set at the conventional level of P value < .05. The analysis was done using SPSS software. Results:RA patients found that 50% of patients had severe depressive symptoms (15 [50%] patients), while only 3 (10%) patients displayed mild symptoms and 6 (20%) patients had moderate symptoms. Italso shows that 20 (66.67%) patients had recurrent depression, another 20 had somatic symptoms, and 16 (53.33%) patients had anxiety.