Caretakers have been described to encounter mental anguish and anxiety throughout the management of household member with mental infirmities. Aim: The study aimed at assessing psychological distress of family caregivers of relatives with mental illness and its burden in EDIM OTOP Community, Calabar. Method: Descriptive strategy was implemented for the study. An expedience selection was employed to select (122) adults that constituted the sample for this study. A survey form was the adopted tool for information assemblage. Information obtained from the survey form was evaluated using expressive measurements whereas the proposition was verified at 0.05 magnitudes. Results: Findings indicate 87(71.3%) study participants said yes to bipolar/affective disorder while 35(28.7%) said no. Lastly on schizophrenia 91(74.6%) said yes while 31(25.4%) said no. Less than half of the respondents, 41(33.6%) identified constant under strain; and 9(7.4%) identified frightening thoughts. Furthermore, despite all other outcomes, 113(92.6%) respondents identified feeling of loneliness. Finding further revealed that maternal age influences the between maternal age and burden of care of caregivers of relatives in EDIM OTOP community. Conclusion: Caretakers been thoughtful of their household associates with psychosis, cerebral ailment and drugs dependence specifically encounter psychological illness, anguish and concern of their sick relatives, however, observations of stress and intervention in their individual existence from obliging interval & possessions to the care of their sick household boons as about constituent of anguish of concern for a cerebrally sick household.