By microwave irradiation, an interpenetrating polymeric network of the diabetes medication Metformin was created using a mix of the biopolymers Psyllium and sodium alginate. The reverse emulsion approach was used successfully to synthesize a metformin Psy-g-Alg nanoparticle. Box-Behnken design was used for the optimization of 33 levels to explore the effects of the independent variables Psy-g-Alg, Span 80, and Speed at three levels (-1, 0 and +1) on the output of the dependent variables particle size and% drug release at 8 h. The optimized Met-IPN-RE formulation was tested for particle size, in vitro drug release, swelling analysis, and XRD. All the research done indicate that this method is safe and effective for the oral delivery of antidiabetic medicines, despite its short elimination half-life and increased bioavailability.