Novel coronavirus pneumonia broke out & gradually developed into a global public health problem. Health care workers, particularly nurses, suffered from great occupational pressure & psychological distress throughout the outbreak of infectious diseases Objective: the objective of the study was to assess the quality of life (QoL) of nurses in Zagazig university hospitals who recovered from COVID-19. Methods: 196 nurses who tested positive for COVID-19 & had already recovered from infection had been included in this cross-sectional investigation. Data was gathered between June and November 2021. Using a validated Arabic version of the World Health Organization Quality of Life questionnaire brief (WHOQOL-BREF), we looked at how COVID affected people's QOL. STATA (Version 26.00) was used for all analyses. Results: the total score of QOL was 75.22 ± 10.93 and ranged from 59 (41 - 100), and regression analysis concluded that age (>30 years group) (p= 0.001) and increased frequency of watching COVID-19 news on TV or on the Internet (p= <0.001) affected each of physical, psychological and social domains of QOL score, Conclusion: quality of life of nurses after COVID was affected by variable interaction of demographic & socioeconomic factors, particularly older age & frequency with which they saw COVID-19 news on TV or the Internet. Health care professionals need to be aware of factors affecting quality of life and intervene on time in post-COVID-19 studied cases with persistent complaints.