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ISSN 2063-5346
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Quantification and in vitro release study of trans ferulic acid by UV spectrophotometric method in tablet dosage form.

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Aarti S. Zanwar*, Ashim K. Sen, Arsh Trunkwala, Rajesh A. Maheshwari, Dipti Gohil, Dhanya B. Sen.
» doi: 10.48047/ecb/2023.12.10.079

Abstract

Many potent bioactive compounds serve as antioxidants in the nutraceutical industry and contribute to the prevention of numerous chronic and degenerative diseases. Also, customers have a highly positive outlook on bioactive compounds because of their additional health and wellness benefits. So, demand for such products has increased in the market. Hence, the development of an analytical method for the rapid and inexpensive quantification of ferulic acid in marketed formulations is very important to ensure that consumers obtain ferulic acid, which gives assurance of the purity of the product. So, the UV spectrophotometric method was developed using the wavelength of maximum absorbance for ferulic acid at 320 nm in methanol for the assay study and 310 nm in phosphate buffer with pH 6.8 for the dissolution study. The linearity and range of the proposed method of ferulic acid calibration curve encompass 5–20 μg/ml and 5–25 μg/ml for assay and dissolution studies, respectively. The variability among the repeatability and intermediate precision studies was less than 2% RSD. The ferulic acid recovered was in the range of 99 to 102 percent from the marketed formulation, recommending that the method can be applied to commercial formulations without the interference of the excipients for both studies.

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