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ISSN 2063-5346
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Quantification and invitro release study of trans Ferulic acid by UV spectrophotometric method in tablet dosage form.

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Aarti S. Zanwar*, Ashim K. Sen, Arsh Trunkwala, Rajesh A. Maheshwari, Dipti Gohil, Dhanya B. Sen.
» doi: 10.31838/ecb/2023.12.4.071

Abstract

Many potent bioactive compounds serve as antioxidants in the nutraceuticals industry and contribute in the prevention of numerous chronic and degenerative diseases. Also, customers have a highly positive outlook on bioactive compounds because of its additional health and wellness gains. So their demand of such product is increased in the market. Therefore, the development of a analytical method for the rapid and inexpensive quantification of ferulic acid in marketed formulation is very important to ensure that the consumers obtain the ferulic acid which give assurance of purity of product. So, the UV Spectrophotometric method was developed using the wavelength of maximum absorbance for ferulic acid at 320 nm in methanol for assay study and 310 nm in Phosphate buffer having pH 6.8 for dissolution study. Linearity and range of the proposed method of ferulic acid calibration curve encompassing of 5-20 μg/ml and 5-25 μg/ml for assay and dissolution studies, respectively. Variability among the repetability and intermediate precision study was less than 2 (% RSD). The ferulic acid recovered in ranged of 97 to 102 percent from the marketed formulation, recommending that the method can be applied for commercial formulation without the interference of excipients for both the studies.

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